开始对银病关节炎综合结果措施的评估:2022年来自GRAPPA-OMERACT工作组的更新
Ying-Ying Leung1, William Tillett2, Maarten de Wit3
1Y.Y. Leung, MB ChB, MD, Duke-NUS Medical School, Singapore, Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; katyccc@hotmail.com.
The Journal of rheumatology
|July 7, 2023
概括
研究人员正在评估牛皮关节炎 (PsA) 的复合结果措施. 最小的疾病活动 (MDA) 是一个高优先级,其他措施,如DAPSA和ACR标准也被考虑PsA评估.
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 临床试验方法论 临床试验方法论
背景情况:
- 牛皮关节炎 (PsA) 需要经过验证的复合结果措施来进行有效的临床评估和研究.
- 牛皮和牛皮关节炎研究和评估小组 (GRAPPA) 和风湿病的结果测量 (OMERACT) 在PsA结果测量开发方面合作.
- 包括患者在内的多学科工作组对于评估这些措施至关重要.
研究的目的:
- 评估和优先考虑评估牛皮关节炎 (PsA) 的复合结果措施.
- 定义目标人群,预期使用,并评估候选PsA工具的优缺点.
- 通过确定最相关的PsA结果措施,为未来的研究和临床实践提供信息.
主要方法:
- 一个工作组由风湿病学家,皮肤病学家,方法学家和患者研究合作伙伴组成.
- 确定并考虑了PSA的十个候选复合结果措施.
- 与工作组和利益相关者一起进行了Delphi初步演习,以衡量措施优先级.
主要成果:
- 最小疾病活动 (MDA) 被确定为PsA的高优先级结果指标.
- 中等优先级被分配给PSA的疾病活动 (DAPSA),美国风湿病学学院 (ACR) 的反应标准,牛皮关节炎疾病活动评分 (PASDAS),复合牛皮疾病活动指数 (CPDAI) 和各种视觉模拟尺度 (VAS).
- 28个关节的疾病活动评分 (DAS28),牛皮关节炎响应者标准 (PsARC) 和例行评估患者指数数据3 (RAPID3) 的优先级较低.
结论:
- GRAPPA-OMERACT PsA工作组正在积极评估综合结果措施.
- 基于Delphi初步演习的优先级指导了对PsA评估工具的进一步评估.
- 正在进行的评估旨在完善和验证牛皮关节炎研究和临床护理中最有效的措施.
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