激素避孕疗法对临床实验室参数的影响:文献综述
Ömer Özcan1,2, Wendy P J den Elzen1,3, Jacquelien J Hillebrand1,2
1Department of Laboratory Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Clinical chemistry and laboratory medicine
|July 7, 2023
概括
激素避孕药 (HC) 显著改变肝脏的结合蛋白的产生,并影响各种临床化学测试. 由于这些变化,对使用HC的女性的测试结果进行仔细解释至关重要.
科学领域:
- 临床化学 临床化学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 激素避孕药 (HC) 被生育年龄的女性广泛使用.
- 了解它们对实验室测试结果的影响对于准确的诊断和监测至关重要.
研究的目的:
- 审查激素避孕药对广泛的临床化学试验的影响.
- 为了评估代谢,肝功能,静血,脏,激素,维生素和矿物质测试的变化.
主要方法:
- 对评估激素避孕药对临床化学参数影响的研究进行系统审查.
- 基于HC剂量,持续时间,成分和服用途径的效果分析.
主要成果:
- 荷尔蒙避孕药显著增加血管酶原水平 (90-375%) 和结合蛋白度 (SHBG,CBG,TBG,VDBP,IGFBP).
- 观察到的结合分子水平的变化包括丸激素,甲状腺激素 (T3,T4),皮质醇,维生素D,IGF1和GH.
- 由于HC类型,路径和剂量的多样性,存在数据限制.
结论:
- 荷尔蒙避孕药的使用主要刺激肝脏的结合蛋白的产生.
- 使用HC的妇女的生物化学测试结果需要仔细解释,考虑到潜在的预分析和方法影响.
- 需要对较新的HC配方和施用途径进行进一步研究.
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