用免疫检查点抑制剂治疗非小细胞肺癌患者的传染性并发症
Matthew Z Guo1, Aanika Balaji1, Joseph C Murray1
1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.
Clinical lung cancer
|July 7, 2023
概括
在接受免疫检查点抑制剂 (ICI) 的非小细胞肺癌患者中,超过一半患有感染. 慢性阻塞性肺病和皮质类固醇使用增加了这些患者住院的风险.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 免疫检查点抑制剂 (ICI) 是非小细胞肺癌 (NSCLC) 的标准治疗方法.
- 在ICI治疗期间感染并发症的发生率和特征尚未得到充分证实.
研究的目的:
- 为了确定ICI治疗的NSCLC患者感染的发病率和特征.
- 鉴定因感染而导致住院和重症监护室 (ICU) 入院的风险因素.
主要方法:
- 对298名从2007年至2020年期间接受ICI治疗的NSCLC患者进行了回顾性研究.
- 关于感染率和结果的描述性统计数据.
- 考克斯的比例危险模型和后勤回归用于识别感染和严重结果的风险因素.
主要成果:
- 感染发生在54.4%的患者中,细菌性肺炎是最常见的.
- 59.3%的感染患者需要住院治疗,15.4%需要接受ICU治疗.
- 慢性肺炎,最近使用皮质类固醇,并发性免疫相关不良事件 (irAE) 和感染与更高的住院几率有关.
结论:
- 在接受ICI治疗的NSCLC患者中,有一半以上患有感染性并发症.
- 患有COPD,最近使用皮质类固醇或并发性irAE/感染的患者面临住院住院风险增加.
- 在NSCLC的ICI治疗期间,对感染的临床意识,包括不寻常的类型,如真菌感染,至关重要.
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