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在血清液中检测恶性瘤的最佳液体体积:一个单一机构的经验
Shaham Beg1, Claudio Zanettini1, Lucio Queiroz2
1Department of Pathology and Laboratory Medicine, New York Presbyterian-Weill Cornell Medicine, New York, New York.
Journal of the American Society of Cytopathology
|July 7, 2023
概括
在血清液中检测恶性瘤需要足够的样本体积. 建议至少服用70毫升的血清液,以实现最佳的细胞病理诊断和改善癌症检测率.
科学领域:
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
- 流体分析 流体分析
背景情况:
- 血清液中的恶性细胞表明晚期癌症,对于治疗决策至关重要.
- 在血清液中检测恶性瘤的最佳样本体积尚未确立.
研究的目的:
- 为了确定血清液的最佳体积,以准确的细胞病理学诊断.
- 为了提高血清液样本中的恶性瘤检测率.
主要方法:
- 分析了来自1134名患者的1597个血清液样.
- 使用国际血清液细胞病理报告系统 (ISRSFC) 进行诊断.
- 进行统计分析,比较各诊断组的临床病理学结果.
主要成果:
- 在从5毫升到5000毫升的样本中检测到恶性病变.
- 较高的样本量显著增加了恶性瘤检测率.
- 总体血清液恶性瘤检测的最佳体积是70毫升.
结论:
- 增加的液体体积与更高的恶性瘤检测率和更低的假阴性率相关.
- 对于最佳的细胞病理学,建议至少提供70毫升的血清液.
- 周心液是一个例外,由于其特征,需要较小的体积.
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