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Updated: Jul 24, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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配方干预以克服低Tg无形药物的动力溶解性降低的方法

Mangesh S Bordawekar1, Madhu Pudipeddi2,3, Colleen E Ruegger1

  • 1Technical Portfolio and Project Management, Technical Research and Development, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, 07936, USA.

AAPS PharmSciTech
|July 7, 2023
PubMed
概括

无形药物NVS-1由于烧结而经历了显著的溶解速率损失,这是一个由湿度和接近其玻璃过渡温度 (Tg) 的温度加剧的粒子聚变过程. 重制努力部分减轻了这种影响,但在高湿度条件下仍然存在挑战.

关键词:
无形盐是一种无形的盐.溶解失败 溶解失败 溶解失败配方优化 优化 配方优化低玻璃过渡温度 (T g)表面聚合 (烧结) 的方法

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