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微生理系统 (MPS) 中吸和毒药物的毒性之间的关系

Ryohei Ueno^1,2, Masahiro Kuninori², Takumi Sumi³

¹Department of Micro Engineering, Kyoto University, Kyoto 615-8540, Japan.

|July 8, 2023

概括

微生理系统 (MPS) 提供先进的药物查,但在药物吸附方面面临挑战. 这项研究强调了环烯聚合物 (COP) 作为一种低吸附材料,强调了为准确的药物毒性评估仔细选择粘合剂.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
药物发现药物发现药物发现

背景情况:

微生理系统 (MPS) 是先进的微流体设备,模仿人体器官进行药物查.
药物吸附到MPS材料上,如聚二甲基 (PDMS) 极大地影响了药物度和毒性评估.
环烯聚合物 (COP) 是PDMS的有希望的低吸附替代品,但面临着粘合挑战.

研究的目的:

评估MPS材料中的药物吸附和毒性,重点是使用COP开发低吸附系统.
为了比较PDMS和MPS中的COP的药物吸附和细胞毒性.
确定最佳的材料组合,以在MPS中进行准确的药物查.

主要方法:

在PDMS和COP材料上评估了疏水性药物环素A的吸附作用.
在基于PDMS和基于COP的MPS中评估药物诱导的细胞毒性.
研究了粘合带对药物可用性和细胞毒性的影响.

主要成果:

疏水性环素A显著吸附到PDMS上,导致PDMS-MPS中观察到的细胞毒性较低.
与PDMS-MPS相比,COP-MPS显示了最小的药物吸附和较高的药物诱导细胞毒性.
用于MPS制造的带吸附了大量的药物,减少了药物的可用性并表现出细胞毒性.

结论:

对于MPS来说,COP是一种可行的低吸附材料,但其粘合需要仔细考虑.
材料选择至关重要:对于基于COP的MPS,建议使用疏水性药物和低细胞毒性结合剂.
优化MPS材料成分对于药物发现中准确的药物疗效和毒性预测至关重要.

关键词:

环烯聚合物 (COP) 是一种环烯聚合物.药物吸附吸附药物吸附的方法药物查对药物进行查.微生理系统 (MPS) 是一种微生理系统.毒性毒性毒性

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