在微毛细管血流下血粘弹性的量化
1Department of Mechanical Engineering, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.
Micromachines
|July 8, 2023
概括
这项研究引入了一种新方法,通过将样本合规性与微流体系统效应分开来测量血液粘性弹性. 这种新方法准确量化了红细胞的弹性,改善了血液流动分析.
科学领域:
- 生物医学工程 生物医学工程
- 微流体学 微流体学
- 类风病学 类风病学 类风病学
背景情况:
- 量化血液弹性对于理解脉动性血液流动至关重要.
- 现有的单一合规模型受到微流体系统特性 (例如软通道,柔性管道) 的显著影响.
- 这种限制阻碍了对血液内在粘性弹性的准确评估.
研究的目的:
- 开发一种新的方法,使血液粘性弹性脱离微流体系统的合规性.
- 引入两个不同的合规系数:一个用于微流体系统 (C1) 和一个用于红细胞 (RBC) 弹性 (C2).
- 为了能够更准确地测量血液粘性弹性,独立于测量装置.
主要方法:
- 使用共流的微流体通道来估计血液粘性弹性.
- 使用流体电路建模推导了接口的控制方程,并分析地解决了它.
- 使用非线性曲线适配来确定两个合规系数 (C1和C2).
主要成果:
- 红细胞弹性与微流体系统符合性 (C2/C1) 的比值估计在10.9和20.4之间,根据通道深度而异.
- 聚甲基 (PDMS) 通道深度增加了两个合规系数;出口管道减少了C1.
- 合规系数和血液粘度都显示出同质与异质硬化红细胞的显著差异.
结论:
- 拟议的双合规系数方法有效地区分了血液粘性弹性和微流体系统效应.
- 这种技术可以准确检测血液特性和微流体系统的变化.
- 未来的应用包括在患者血液样本中检测红细胞亚种群.
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