在检查点封锁后,B细胞在免疫相关不良事件中的作用
Kavita M Dhodapkar1,2, Alyssa Duffy1, Madhav V Dhodapkar2,3
1Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatric Hematology/Oncology, Emory University, Atlanta, Georgia, USA.
免疫检查点阻塞 (ICB) 治疗癌症可能导致免疫相关不良事件 (irAEs). 本综述探讨了B细胞和自身抗体在irAEs中的作用,强调需要更好地了解T:B细胞相互作用.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 这是一种自身免疫力.
背景情况:
- 免疫检查点封锁 (ICB) 已经彻底改变了癌症治疗.
- 免疫相关不良事件 (irAEs) 是一个重大的临床挑战.
- B细胞与自身免疫有关,可能在irAEs中发挥作用.
研究的目的:
- 审查幽默免疫,B细胞子集和自身抗体在ICB诱导的irAEs中的作用.
- 突出需要了解在irAE病原发生过程中T:B细胞交叉的需要.
- 确定预防或治疗IRE的潜在目标.
主要方法:
- 文献综述侧重于B细胞子集,自身抗体和irAEs.
- 对与ICB相关的B细胞变化的现有数据的分析.
- 在ICB治疗的背景下检查T:B细胞相互作用.
主要成果:
- ICB与B细胞种群的特定变化有关.
- 这些B细胞变化与irAEs的发展相关.
- 在irAEs中T:B细胞交叉的精确机制尚未完全理解.
结论:
- B细胞和自身抗体可能是ICB诱导的IRAE的贡献者.
- 对T:B细胞相互作用的进一步研究对于管理irAEs至关重要.
- 了解这些机制可能会导致改善ICB治疗和irAE管理.
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