葡萄牙风湿性关节炎患者在生物治疗中的严重感染 - 一个多中心,全国性研究 (SIPPRA-B研究)
Filipe Oliveira Pinheiro1, Maria Seabra Rato1, Pedro Madureira1
1Serviço de Reumatologia, Centro Hospitalar Universitário de São João.
ARP rheumatology
|July 8, 2023
概括
在类风湿性关节炎 (RA) 中,生物修饰性抗风湿药物 (bDMARD) 具有传染性风险. 这项研究确定了bDMARDs的RA患者严重感染 (SI) 的预测因素,帮助治疗决策.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 药物监督 药物监督 药物监督
背景情况:
- 对于在类风湿性关节炎 (RA) 中使用不同生物修饰性抗风湿药物 (bDMARDs) 的传染性风险的了解有限.
- 需要在接受bDMARD治疗的RA患者中确定严重感染 (SI) 的预测因子.
研究的目的:
- 评估葡萄牙RA患者治疗bDMARDs的严重感染 (SI) 的发生率和类型.
- 为了确定bDMARDs的RA患者中SI的预测因子.
主要方法:
- 回顾性多中心队列研究,使用来自葡萄牙风湿病登记处 (Reuma.pt) 的数据.
- 与没有严重感染 (SI) 的RA患者进行比较,需要住院治疗,服用肠道抗生素或导致死亡.
- 后勤回归分析以确定SI的独立预测因素.
主要成果:
- 总共有3394名RA患者被分析;4.2%的人患有严重感染 (SI).
- 独立的SI预测因素包括慢性病,喘,使用infliximab,使用皮质类固醇,间歇性肺病,先前的骨科手术,以及更高的HAQ/DAS28分数.
- 大多数SIs发生在第一个bDMARD时,往往导致治疗中止.
结论:
- 这项研究提供了关于葡萄牙RA患者使用bDMARDs的SI发病率和类型的真实数据.
- 确定SI的预测因子可以为治疗决策和RA患者的生物药物风险分层提供信息.
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