侧侧跨部在办公室内注射肉毒素用于逆行式喉功能障碍
1Center for Voice and Swallowing, Department of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York, U.S.A.
The Laryngoscope
|July 8, 2023
概括
在办公室内注射肉毒素 (BTX) 治疗喉功能障碍是安全的,但效果不如手术室手术. 副作用率相似,突出了潜在的优势,尽管办公室内方法的成功率较低.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 最少侵入性手术的方法
- 神经调节是一种神经调节.
背景情况:
- 逆行式喉功能障碍 (RCPD) 是一种影响吞和发声的疾病.
- 在手术室 (OR) 中注射肉毒素 (BTX) 是对RCPD的一种既定治疗方法.
- 在办公室 (IO) 程序在成本和患者方便方面提供了潜在的优势.
研究的目的:
- 在办公室环境中通过横向的宫横向方法,评估30个BTX注射到大肌的单位的疗效和安全性.
- 为了比较IO BTX注射与传统OR BTX注射在RCPD管理中的结果.
- 通过比较早期和晚期程序成功率来评估IO BTX注射的学习曲线.
主要方法:
- 对接受RCPDBTX注射的患者的回顾性图表审查,比较OR和IO组.
- 评估的结果包括手术后的成功 (通过症状缓解来定义),副作用和并发症率.
- 使用奇平方测试的统计分析被用来确定显著性.
主要成果:
- 总共分析了78个注射 (37个IO,41个OR).
- 在一个月的随访中,OR注射的成功率 (90.2%) 与IO注射 (64.9%) 相比显著更高 (p=0.022).
- 两组之间没有观察到副作用率的显著差异,早期和晚期IO注射的成功率相似.
结论:
- 在办公室内,RCPD的横向宫过BTX注射是一种安全的程序,不需要麻醉.
- 虽然IO注射提供了优势和与OR程序相似的副作用概况,但它们的成功率较低.
- 进一步的研究可能会探索优化IO技术,以提高RCPD治疗的疗效.
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