传统心血管风险因素对大脑白质的贡献强度过高
Fatemeh Koohi1, Eric L Harshfield1, Hugh S Markus1
1Stroke Research Group Department of Clinical Neurosciences University of Cambridge Cambridge United Kingdom.
Journal of the American Heart Association
|July 8, 2023
概括
白质超强度 (WMH) 的风险并不能完全由心血管因素来解释. 需要进一步的研究来确定其他血管和非血管对WMH发展的贡献者,以便制定更好的预防策略.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 白质超强度 (WMHs) 是中风和痴呆的重要危险因素.
- 目前尚不完全了解WMHs的确切病原和常规心血管风险因素 (CVRFs) 的贡献.
- 了解这些因素对于制定有效的预防策略至关重要.
研究的目的:
- 调查由CVRFs,性别和年龄解释的WMH体积变异的比例.
- 确定有助于WMH发展的特定CVRF.
- 探索影响WMH病变的潜在未知因素.
主要方法:
- 分析了来自41,626名英国生物库参与者的脑磁共振成像数据.
- 利用相关性和结构方程模型来检查CVRFs和WMH体积之间的关系.
- 评估了年龄,性别和各种CVRFs对WMH体积的影响,以总大脑体积的百分比计算.
主要成果:
- 总体而言,CVRFs,性别和年龄仅解释了WMH体积变异的32%,年龄占16%.
- 综合的CVRF解释了差异的约15%,血压参数贡献了约10.5%.
- 很大一部分 (超过60%) 的WMH变异仍然无法解释,个人CVRF的影响通常随着年龄的增长而下降.
结论:
- 传统的CVRFs,特别是高血压,发挥作用,但不能完全考虑到WMH的发展.
- 显著的不明原因变异表明其他血管和非血管因素的参与.
- 进一步的研究是必要的,以确定这些未知的风险因素,以改善WMH预防.
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