益生菌使用与nivolumab对各种癌症有效性的关联:一个多中心的回顾性队列研究
Junya Arai1,2, Ryota Niikura3, Yoku Hayakawa1
1Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
益生菌可以提高胃癌患者的尼沃卢马布治疗持续时间. 这项研究在其他癌症中没有发现整体效果,但表明对特定的胃肠道癌症有潜在的益处.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠病学 胃肠病学
背景情况:
- 以前的研究将益生菌与改善免疫检查点抑制剂 (ICI) 在癌和肺癌中的疗效联系起来.
- 关于益生菌对胃肠道 (GI) 癌症的影响的数据有限.
研究的目的:
- 在各种癌症类型中调查益生菌使用和尼沃卢马布治疗持续时间之间的关联.
- 专门研究益生菌对肠胃癌患者nivolumab治疗的影响.
主要方法:
- 一个多中心的回顾性队列研究包括488名接受nivolumab的患者.
- 在益生菌使用者和非使用者之间比较nivolumab治疗持续时间.
- 分析了整体癌症类型,特别是胃癌的数据.
主要成果:
- 在所有癌症类型中,在益生菌使用者和不使用者之间没有观察到尼沃卢马布治疗持续时间的显著差异 (中位数为62.0天与56.0天).
- 使用益生菌的胃癌患者的尼沃卢马布治疗持续时间显著更长 (55.0 vs 31.0 天).
- 在胃癌的益生菌使用者中,短期治疗的危险比为0.69 (p=0.039).
结论:
- 益生菌的使用可能不会在所有癌症中普遍影响nivolumab治疗持续时间.
- 益生菌与胃癌患者长期接受尼沃卢马布治疗有显著的关联.
- 研究结果表明,益生菌在改善尼沃卢马布反应和胃癌无进展生存方面可能发挥作用.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
相关概念视频
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Treatment Resistant Cancers
