在患有自主皮质醇分泌患者的炎症和心血管生物标志物的实质性变化
Grethe Å Ueland1, Paal Methlie1,2, Anette Heie3
1Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.
European journal of endocrinology
|July 8, 2023
概括
患有自主皮质醇分泌 (ACS) 和库希综合征 (CS) 的患者显示炎症生物标志物升高. 这些生物标志物与高皮质醇不相关,并且在治疗后没有正常化.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 自主皮质醇分泌 (ACS) 和库希综合征 (CS) 是一种皮质醇过度产生的情况.
- 炎症在各种慢性疾病中起着重要作用,但其与皮质醇过剩疾病的关联尚未完全理解.
研究的目的:
- 在患有ACS和CS的患者中全面地绘制炎症生物标志物的概况.
- 为了比较患有ACS,CS和健康个体之间的炎症生物标志物水平.
- 研究炎症生物标志物,高皮质醇和治疗结果之间的关系.
主要方法:
- 一项观察性研究涉及从患有ACS (n=63),上腺CS (n=2),垂体CS (n=8) 和健康对照组 (n=120) 的患者的血清样本.
- 使用奥林克近距离延伸试验对92种炎症生物标志物的分析.
- 生物化学治疗后从一小部分患者中评估术后样本.
主要成果:
- 与健康对照组相比,患有ACS和CS的患者表现出92个炎症生物标志物中的49个水平显著变化 (46个增加,3个减少).
- 在ACS和明显的CS组之间没有观察到炎症生物标志物水平的显著差异.
- 在炎症生物标志物水平和高皮质醇度之间没有发现相关性.
- 术后分析显示,即使在成功的生化疗法后,这些炎症生物标志物也没有显著的正常化.
结论:
- 在患有ACS和CS的患者中,炎症生物标志物的全身升高存在.
- 观察到的炎症变化与高皮质醇症的严重程度没有直接相关.
- 炎症生物标志物在皮质醇过剩疾病的手术或医疗治疗后似乎没有正常化.
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