相关实验视频

Updated: Jul 24, 2025

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

药物自我聚合成纳米实体有可能诱导免疫反应

Fatma Shahout¹, Marion Vanharen¹, Abdelaziz Saafane¹

¹Université du Québec, INRS-Centre Armand-Frappier Santé Biotechnologie, 531 Boulevard des Prairies, Laval, Québec H7V 1B7, Canada.

Molecular pharmaceutics

|July 8, 2023

概括

小分子药物纳米实体可以在溶液中形成,并可能触发免疫反应. 这项试点研究观察到一些药物聚合物暴露的免疫细胞中IL-8和TNF-α的增加.

科学领域:

制药科学制药科学
免疫学免疫学免疫学
材料科学材料科学材料科学

背景情况:

溶液中的小分子可以作为可溶性单体,自组装的纳米实体或固体沉物存在.
新兴证据将药物纳米实体与意想不到的副作用联系起来.
了解这些行为对于药物的安全性和有效性至关重要.

研究的目的:

调查药物纳米实体和免疫反应之间的潜在相关性.
探索水溶液中药物自组的形成和检测.
评估药物聚合物对免疫细胞模型的影响.

主要方法:

利用核磁共振 (NMR),动态光散射 (DLS),传输电子显微镜 (TEM) 和共聚焦显微镜进行纳米实体检测.
使用酶链接免疫吸收试验 (ELISA) 来监测免疫反应.
在小鼠巨细胞和人类中性粒细胞模型上测试药物和染料化合物.

主要成果:

成功检测到自组装成纳米实体的选择药物和染料.
观察到暴露于某些药物聚合物和增加的IN-8 (IL-8) 和瘤坏死因子-α (TNF-α) 的水平之间的相关性.
在小鼠和人类细胞模型中证明了免疫反应的调节.

结论:

这项试点研究表明,药物纳米实体与免疫系统调节之间存在联系.
进一步的大规模调查是有必要的,以探索药物诱导的免疫相关的副作用.
这些发现强调了在药物开发和安全性评估中考虑分子自我组装的重要性.

关键词:

自由状态解决方案的行为.免疫反应的免疫反应.纳米实体是一个实体.有关副作用的副作用是什么?三相平衡的三相平衡是什么

更多相关视频

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry

Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry

Published on: March 28, 2014

相关概念视频

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...