细分切除术或分叶切除术后肺癌患者的肺功能变化:一项回顾性,非干预性,观察性研究
Minwei Bao1, Zhongping Lang2, Zhuofu Wang3
1Department of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, China.
概括
单个肺细分切除术 (SSE) 在早期肺癌中比多重细分切除术 (MSE) 或分叶切除术 (LE) 更好地保护肺功能. 与LE相比,MSE还显示出更好的肺功能保护.
科学领域:
- 胸部外科手术 胸部外科手术
- 肺部医学 肺部医学
- 在瘤学瘤学.
背景情况:
- 肺部细分切除术 (SE) 越来越多地用于早期肺癌.
- 比较单个SE (SSE),多个SE (MSE) 和叶切除术 (LE) 对于理解术后肺功能至关重要. 非小细胞肺癌 (NSCLC) 的治疗决定会影响长期结果.
研究的目的:
- 为了比较SSE,MSE和叶片切除术 (LE) 对NSCLC患者术后肺功能的影响.
- 为了评估不同手术切除方法后肺功能下降的差异.
主要方法:
- 对1284名接受LE (493),SSE (558) 或MSE (233) 的NSCLC患者的回顾性分析.
- 肺功能测试 (PFTs) 进行了手术前和手术后12个月.
- 在手术组中比较PFT值和观察/预期 (O/E) 损失比率.
主要成果:
- 与MSE和LE相比,SSE的PFT价值下降幅度明显较小.
- 整体肺功能损失在LE后比SSE或MSE后更大.
- MSE导致了比SSE更大的PFT下降,但仍然比LE更好.
结论:
- 在早期NSCLC中,SSE提供了术后肺功能的最佳保存.
- 虽然MSE导致比SSE更大的PFT下降,但它仍然是一个比LE更节省肺部的选择.
- 无论是LE还是SE,每个细分市场均表现出类似的PFT损失,但总体功能损失根据切除的程度显著不同.
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