耐力运动压力:生长激素处理和从前垂体体内生长细胞中释放的理论机制
Wesley C Hymer1, William J Kraemer2,3,4,5
1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
European journal of applied physiology
|July 8, 2023
概括
重力运动 (HRE) 有效地刺激肌肉生长和像生长激素 (GH) 这样的合成激素. 本综述探讨了HRE如何影响GH分泌途径和垂体腺中的分泌颗粒.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 分子生物学分子生物学
背景情况:
- 重力阻力运动 (HRE) 是肌肉缩和合成激素,特别是生长激素 (GH) 的释放的主要刺激.
- pituitary somatotroph细胞是GH合成和分泌的核心,涉及复杂的细胞内处理和释放机制.
- 了解GH分泌的调节对于优化训练适应和荷尔蒙反应至关重要.
研究的目的:
- 探索 pituitary somatotroph GH分泌途径中的分子机制.
- 调查分泌颗粒作为GH释放中的信号枢纽的作用.
- 审查HRE如何影响分泌的GH的数量和质量,并考虑体的异质性.
主要方法:
- 对研究GH分泌途径的文献综述.
- 对分泌颗粒在激素释放中的作用的研究分析.
- 检查将HRE与GH分泌参数相关联的数据.
主要成果:
- 在 pituitary somatotrophs 中,HRE 影响GH 的合成,包装和异细胞形成.
- 分泌颗粒在调节GH释放方面发挥着重要作用,作为信号枢纽.
- HRE影响释放的GH的数量和特征,其中的变化可能与体群体差异有关.
结论:
- 沉重的阻力运动调节了在垂体水平上复杂的GH分泌途径.
- 分泌颗粒是GH释放的关键调节者,是对HRE的反应.
- 对体的异质性的进一步研究可能会阐明个性化GH对运动的反应.
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