相关实验视频

Updated: Jul 24, 2025

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Published on: December 16, 2018

源自犬胎膜的介质干细胞通过再生和免疫调节改善亚托皮炎

Min Soo Kim¹, Dasom Kong¹, Myounghee Han²

¹Adult Stem Cell Research Center, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.

Veterinary research communications

|July 8, 2023

概括

狗羊膜介质干细胞 (cAM-MSCs) 显示出强大的免疫调节效应,在小鼠模型中有效治疗狗皮炎. 这些干细胞为oclacitinib提供了一个更安全的替代品,促进再生,没有不良副作用.

科学领域:

兽医医学兽医医学兽医医学
免疫学免疫学免疫学
再生医学是一种再生医学.

背景情况:

介质细胞干细胞 (MSCs) 在免疫疾病方面得到了探索.
与商业生物制剂相比,犬类MSCs的免疫调节能力仍未得到充分研究.

研究的目的:

调查犬膜衍生MSCs (cAM-MSCs) 的特征和免疫调节作用.
为了比较cAM-MSCs与oclacitinib (OCL) 的治疗疗效,用于治疗犬类亚型皮肤炎 (AD).

主要方法:

对免疫调节标记物 (TGF-β1,IDO1,PTGES2) 和T细胞增殖的基因表达分析.
使用小鼠AD模型进行体内疗效研究,比较cAM-MSCs,OCL和PBS治疗.
评估皮肤症状,组织病理学,炎症性细胞因子和巨细胞活动.

主要成果:

cAM-MSCs提高了关键免疫调节基因的调节,并抑制了T细胞的增殖.
与PBS相比,cAM-MSCs显著减少了AD症状,炎症和病理变化.
cAM-MSCs在伤口愈合和巨细胞调节方面表现出优于OCL的疗效,没有负面的体重影响.

结论:

cAM-MSCs具有显著的免疫调节和再生特性,有利于治疗犬类亚托皮炎.
cAM-MSCs代表了对犬类AD的有希望的,安全的治疗选择,由于有利的副作用概况,可能会超过OCL等当前治疗方法.

关键词:

亚托邦性皮肤炎 (AD)狗类犬类动物狗类犬类狗的羊膜膜 (cAM) 是一种介质细胞干细胞 (MSCs) 是一种干细胞.奥克拉西替尼 (OCL) 是一种

更多相关视频

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Published on: April 7, 2023

相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...