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混合的IgG Fc免疫复合体表现出混合的结合特征,并改进FcR亲缘关系估计

Zhixin Cyrillus Tan1, Anja Lux2, Markus Biburger2

  • 1Bioinformatics Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

Cell reports
|July 8, 2023
PubMed
概括

这项研究揭示了免疫球蛋白G (IgG) 抗体的混合物如何调节免疫反应. 一个新的模型准确地预测Fcγ受体结合和效应器功能,甚至对于IgG2,改善了我们对免疫细胞相互作用的理解.

关键词:
CP: 免疫学 免疫学在Fcγ Fcγ亲和关系是一种亲和关系.抗体是对抗体的重要组成部分.这就是贪,贪.效应器的功能是效应器的功能.免疫学 免疫学 免疫学这些受体是受体受体.

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Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...