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对影响乳腺发育的孕产妇和产周因素进行系统审查
Michela Dalmartello1, Francesca Chiaffarino2, Giovanna Esposito1
1Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Early human development
|July 8, 2023
概括
母亲因素,如高体重和早期体重增加,与早期乳腺发育有关. 过早分娩与较晚的乳腺发育有关,影响青春期的开始.
科学领域:
- 生殖健康 生殖健康
- 儿科内分泌学 儿科内分泌学
- 环境健康 环境健康
背景情况:
- 世俗趋势表明初潮较早,但乳腺发育趋势的理解较少.
- 早期的暴露可能会影响青春期的时间和乳腺发育.
- 了解这些影响对于评估长期健康结果至关重要.
研究的目的:
- 审查将子宫和生命早期事件与乳腺发病和发育联系在一起的证据.
- 为了确定与青春期时间相关的产前和早期儿童因素.
- 综合当前关于环境对乳腺发育影响的研究.
主要方法:
- 来自PubMed和Embase数据库的研究的系统审查.
- 包括测量胎儿或生命早期暴露及其与乳腺发育的关联的研究.
- 分析了来自43个队列和横截面研究的数据.
主要成果:
- 高孕产妇体重,初级孕产妇和早期孕产妇体重增加与早期乳腺发育风险增加有关.
- 过早分娩与晚期乳腺发育有关.
- 在怀孕期间吸烟,孕产妇高血压疾病,母乳养,糖尿病和妊娠年龄小的不一致的关联被发现.
结论:
- 孕产妇和早期生活因素显著影响乳腺发育时间.
- 青春期早期发作可能会对终身健康产生影响.
- 需要进一步的多学科研究来澄清产前/产后暴露对青春期的影响.
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