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在精神病症中出现突出网络切换的损伤
Philip Deming1, Cole J Cook2, Mary E Meyerand3
1Department of Psychology, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
Behavioural brain research
|July 8, 2023
概括
突出网络 (SN) 有助于在大脑网络之间转移注意力. 在精神病症中,这种SN切换作用减弱,影响了注意力分配. 这一发现支持了心理病中大脑功能的新理论.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 精神病与大脑网络连接的改变有关,影响了注意力.
- 默认模式网络 (DMN),前端对象网络 (FPN) 和突出网络 (SN) 是注意的关键.
- 在DMN和FPN之间切换中,SN的作用对于有效的注意力分配至关重要.
研究的目的:
- 调查突出网络 (SN) 在精神病患者的默认模式网络 (DMN) 和前端对象网络 (FPN) 之间切换中的作用.
- 测试SN的切换功能在精神病症中减弱的假设.
主要方法:
- 来自148名被监禁男子的休息状态fMRI数据使用独立组件分析来识别DMN,FPN和SN活动.
- 使用动态因果建模来评估SN在DMN和FPN之间切换中的作用.
主要成果:
- 在低精神病态参与者中,SN在DMN和FPN之间的切换效应被复制.
- 在高精神病参与者中观察到,SN的切换作用显著减少.
结论:
- 这些发现支持了精神病中大脑功能的新理论,突出了受损的SN切换机制.
- 干扰的SN切换可能是高度精神病态的个体的异常注意力分配的基础.
- 这个模型为未来关于精神病症和注意力缺陷的研究提供了一个框架.
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