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Updated: Jul 24, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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一种新的转录因子组合,用于直接重新编程到自发收缩的人类心肌细胞样状态

Marisol Romero-Tejeda1, Hananeh Fonoudi1, Carly J Weddle1

  • 1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Journal of molecular and cellular cardiology
|July 8, 2023
PubMed
概括

研究人员发现了一种转录因子 (MST) 的新组合,该组合能够成功地将人类纤维细胞重新编程成类似心肌细胞的细胞. 这一突破推动了潜在的再生医学应用的直接心脏重编程.

关键词:
循环是因为循环.一个心肌细胞.直接进行重编程.纤维细胞母细胞细胞.高通量的高通量.自发的收缩是自发的收缩.

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