强化心律监测以减少缺血性中风和全身血栓塞-Find-AF 2研究-理性和设计
Tobias Uhe1, Katrin Wasser2, Mark Weber-Krüger3
1Department of Cardiology, University Hospital Leipzig, Leipzig, Germany.
American heart journal
|July 8, 2023
概括
这项研究调查了加强心律监测,导致口服抗凝剂 (OAC),是否可以减少由心房动 (AF) 引起的复发性中风. 加强监测旨在改善中风患者的心血管栓塞预防.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 临床试验 临床试验
背景情况:
- 心房动 (AF) 是中风的主要原因.
- 长期监测检测到更多的AF病例,但其对预防复发性心血管栓塞的影响尚不清楚.
- 口服抗凝剂 (OAC) 是AF相关中风预防的关键治疗方法.
研究的目的:
- 评估风险调整,加强心律监测和随后的OAC治疗是否可以减少复发性心血管栓塞.
- 为了比较加强监测策略与标准护理在预防二次中风.
主要方法:
- Find-AF 2试验是一个随机的,受控的多中心试验,涉及5,200名年龄≥60岁的近期缺血性中风患者,没有已知的AF.
- 患者随机分配到增强的,长时间的心电图监测 (包括高风险个体的植入式心脏监测器) 或标准监测.
- 主要终点是复发性缺血性中风或全身血栓塞的时间,随访时间至少为24个月.
主要成果:
- 这个部分不在所提供的摘要中.
结论:
- 在Find-AF 2试验假设,增强,长时间的节律监测将导致更有效的预防复发性缺血性中风和全身血栓塞与通常护理相比.
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