在B细胞成熟中的TACI和内源性APRIL
Yolanda Garcia-Carmona1, Miguel Fribourg2, Allison Sowa3
1Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA.
Clinical immunology (Orlando, Fla.)
|July 8, 2023
概括
TACI-S蛋白质异型对终端B细胞分化为血细胞至关重要. 细胞内TACI-S,BCMA和APRIL合作指导这一过程,确保血细胞的存活.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 生殖中心B细胞的反应是产生抗体的关键,但终端分化途径尚未完全理解.
- TACI基因的突变与常见的可变免疫缺陷,B细胞分化受损和自身免疫性疾病有关.
- 人类B细胞表达TACI-L和TACI-S异型,其中TACI-S特别促进血细胞分化.
研究的目的:
- 研究细胞内TACI-S,BCMA和APRIL在终端B细胞分化中的作用.
- 阐明B细胞末端分化和血细胞存活背后的分子机制.
主要方法:
- 在B细胞激活过程中分析细胞内TACI-S表达及其与BCMA和APRIL的同位化.
- 在失去了APRIL时对同型类别切换,代谢和转录变化的评估.
- 关于细胞内TACI-S,BCMA和APRIL对血细胞分化和生存的贡献的研究.
主要成果:
- 细胞内TACI-S表达随着B细胞激活而增加,并与BCMA和APRIL.
- 失去APRIL显著损害同型类别切换,并诱导明显的代谢和转录变化.
- 细胞内TACI-S,BCMA和APRIL对于长期的血细胞分化和生存至关重要.
结论:
- 细胞内TACI-S与BCMA和APRIL一起,在指导终端B细胞分化成血细胞方面发挥着关键作用.
- 这种分子复合体对于维持血细胞种群和确保持续抗体生产至关重要.
相关概念视频
B Cell Activation and Differentiation
1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
Diversity of Antigen Receptors
655
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
655
T Cell Activation and Clonal Selection
832
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
832
Cells of the Adaptive Immune Response
1.1K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.1K
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Antigen Presenting Cells
1.9K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.9K


