在免疫功能低下的个体中进行无限期干扰素马释放试验时,进展到活性结核病的风险:系统性审查和元分析
Guozhong Zhou1, Shiqi Luo2, Jian He3
1Department of Science and Research, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China.
概括
在免疫受损个体中,不确定的干扰素马释放试验 (IGRA) 结果表明活跃结核病 (TB) 进展的中间风险. 这些结果表明,谨慎管理对于减轻这一群体的结核病风险至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 评估针对潜伏结核病感染 (LTBI) 查的免疫功能低下个体的活跃结核病 (TB) 风险的数据有限.
- 干扰素释量测试 (IGRA) 用于LTBI查,但不确定的结果在风险评估中构成了挑战.
结论:
- 在免疫受损个体中,不确定的IGRA结果代表了活跃结核病进展的中间风险.
- 这种风险大约是IGRA阳性结果的一半,是IGRA阴性结果的近三倍.
- 对于具有不确定的IGRA结果的患者,适当的后续和管理策略对于有效的结核病风险减轻至关重要.
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