在墨西哥前青少年心脏代谢风险因素的集群
Sonia Tandon Wimalasena1, Claudia Ivonne Ramirez Silva2, Yan V Sun3
1Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA.
Diabetes research and clinical practice
|July 8, 2023
概括
这项研究比较了评估墨西哥儿童心脏代谢健康的两个分数. 代谢综合征 (MetS) 评分和探索性心脏代谢健康 (CMH) 评分都显示出类似的变化,有助于风险识别.
科学领域:
- 儿科心脏病学 儿科心脏病学
- 代谢健康研究研究
- 墨西哥的公共卫生.
背景情况:
- 全球范围内,心脏代谢风险因素在儿科患者中越来越多.
- 早期识别心脏代谢风险对于预防长期疾病至关重要.
- 墨西哥儿童在代谢健康方面面临着独特的公共卫生挑战.
研究的目的:
- 为了研究11岁墨西哥儿童心脏代谢标记的聚类.
- 为了比较标准代谢综合征 (MetS) 评分与探索性心脏代谢健康 (CMH) 评分的实用性.
- 评估MetS和CMH分数在识别风险中的可靠性和一致性.
主要方法:
- 用POSGRAD出生队列 (n=413) 的数据进行心脏代谢评估.
- 使用主要组件分析 (PCA) 来得出MetS和CMH分数.
- 包括adipokines,脂质,炎症标志物和脂肪在CMH得分中进行更广泛的评估.
主要成果:
- 42%的参与者表现出至少一个心脏代谢风险因素.
- 低高密度脂蛋白 (HDL) 胆固醇 (31.9%) 和高甘油 (18.2%) 是最常见的.
- 肥胖和脂质测量是MetS和CMH分数变化的关键驱动因素;分数之间的一致性为67% (κ=0.42).
结论:
- 无论是MetS还是CMH分数都有效地捕捉了心脏代谢标志物的显著变化.
- 通过包括额外的标记,CMH评分提供了潜在的更广泛的评估.
- 建议进行进一步的研究,比较这些分数的预测能力,以改善儿科风险识别.
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