与破裂大脑动脉瘤形患者不良临床表现相关的因素
Joseph H Garcia1, Luis Carrete1, W Caleb Rutledge1
1Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
World neurosurgery
|July 8, 2023
概括
吸烟和相关动脉瘤与大脑动脉静脉形 (bAVM) 破裂后的更糟糕结果相关. 识别这些风险因素可以改善患者的预后,并指导破裂的bAVMs的临床决策.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 破裂的大脑动脉静脉形形 (bAVMs) 可以导致严重的患者残疾.
- 现有的临床分级系统可以预测预后,但提供有限的治疗指导.
- 需要确定与糟糕结果相关的破裂前特征.
研究的目的:
- 确定与破裂bAVM患者呈现时不利等级相关的临床,人口和形态变量.
- 探索与格拉斯哥昏迷量表 (GCS) 和亨特-赫斯分数相关的因素.
主要方法:
- 对121名患有破裂的bAVM的患者进行了回顾性审查.
- 线性回归模型用于评估患者/AVM特征与GCS/亨特-赫斯得分之间的关联.
主要成果:
- 吸烟史与较低的GCS和较差的亨特-赫斯分数有关.
- 相关动脉瘤与较低的GCS相关,并趋向于更差的亨特-赫斯得分.
- 破裂时的平均年龄为28.5岁,51%的患者是女性.
结论:
- 患者吸烟状态和相关动脉瘤的存在是bAVM破裂后不良临床等级的适度预测因素.
- 这些发现表明风险分层和干预的潜在目标.
- 需要使用特定于AVM的尺度进行进一步的研究,以确认其临床效用.
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