相关实验视频

Updated: Jul 24, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

评估药物物质颗粒大小的新技术在复杂的吸入配方中

Daniel P Dobson¹, Miguel Saggu¹, Jackson D Pellett¹

¹Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.

Journal of pharmaceutical sciences

|July 8, 2023

概括

本研究提出了一种新的激光衍射方法,用于测量干粉吸入器中活性药物成分 (API) 颗粒大小稳定性. 较低的药物负载提高了API粒子的稳定性,这可能是由于凝聚性相互作用减少.

科学领域:

制药技术制药技术制药技术
粒子科学粒子科学
药物输送系统药物输送系统

背景情况:

干粉吸入器 (DPI) 使用活性药物成分 (API) 和载体辅助物质进行肺部药物输送.
在DPI配方中保持API颗粒大小稳定性对于一致的空气动力学性能至关重要.
测量API粒子大小是具有挑战性的,因为在标准激光衍射中,高辅助剂度会掩盖API信号.

研究的目的:

开发一种新的激光衍射方法,用于准确测量DPI中的API粒子大小稳定性.
调查药物负载对DPI配方中的API颗粒大小稳定性的影响.
了解药物负载,凝聚性相互作用和颗粒大小稳定性之间的关系.

主要方法:

开发了一种新的激光衍射技术,利用API和助剂之间的溶解度差异.
该方法用于分析DPI混合物中各种药物加载度的API颗粒大小稳定性.
配方混合物的特征是为了评估药物加载效应和潜在的凝聚性相互作用.

主要成果:

这种新的方法成功测量了API颗粒大小稳定性,克服了高辅助剂水平带来的挑战.
与高药载荷配方相比,低药载荷配方显示出明显更好的API颗粒大小稳定性.
在较低的药物负载配方中减少的凝聚性相互作用被认为是改善颗粒大小稳定的原因.

结论:

开发的激光衍射方法为DPI中的API粒子稳定性提供了宝贵的见解.
药物负载是影响API粒子大小稳定的关键因素,较低的负载更稳定.
了解这些稳定性动态对于优化DPI配方设计和确保有效的肺药物递送至关重要.

关键词:

粘合剂混合物粘合剂混合物混合状态混合状态药物产品的稳定性药物产品的稳定性干粉吸入器干粉吸入器激光衍射激光是一种激光.微化的微化.粒子大小融合的粒子大小.可以呼吸的大小.

更多相关视频

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Published on: July 18, 2014

相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

Methods for Studying Drug Absorption: In situ

Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...