呼吸道同胞病毒疫苗和单克隆抗体的价值概况
Jessica A Fleming1, Ranju Baral1, Deborah Higgins1
1Center for Vaccine Innovation and Access, PATH, 2201 Westlake Ave Suite 200, Seattle, WA 98121, United States.
Vaccine
|July 8, 2023
概括
对于儿童而言,目前还没有获得许可的呼吸道同胞性病毒 (RSV) 疫苗,但母体疫苗和婴儿单克隆抗体 (mAbs) 对预防有希望. 这些干预措施可能具有成本效益,并在1-3年内可行.
科学领域:
- * 公共卫生和疫苗学
- * 预防传染病预防工作
- * 儿科健康 儿科健康
背景情况:
- *呼吸道同胞性病毒 (RSV) 是全球幼儿急性下呼吸道感染 (ALRI) 的主要原因.
- *目前的预防选择,如单克隆抗体 (mAb) 预防,是有限的,昂贵的,并且不适合广泛使用,特别是在低收入环境中.
- * 对于婴儿和儿童的有效和可访问的RSV预防策略,存在着至关重要的未满足需求.
研究的目的:
- * 评估新兴RSV疫苗和类似疫苗产品的潜在公共卫生,经济和社会价值.
- * 确定有关RSV预防策略的当前研究和知识差距.
- * 为未来RSV干预措施的开发和实施提供信息.
主要方法:
- * 开发针对RSV的疫苗价值概况 (VVP).
- *对可用数据的整体评估管道中的RSV疫苗和被动免疫方法.
- * 专家工作组与来自学术界,非营利组织,公私伙伴关系,多边组织和世卫组织的利益相关者合作.
主要成果:
- * 对于低收入环境而言,有两种有前途的被动免疫接种方法:母体RSV疫苗和长效婴儿mAbs.
- *可在一年至三年内对一个或多个候选人进行可行许可.
- *经济模型表明,母体疫苗和婴儿mAbs都可能具有成本效益.
结论:
- * 孕产妇RSV疫苗和婴儿mAbs是预防小儿群体RSV疾病的可行策略.
- *有效,高效和公平的疫苗接种需要在母婴健康计划和免疫计划之间进行强有力的协调.
- *需要进一步的研究和数据来解决知识差距,并优化这些新兴干预措施的价值.
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