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向右不平衡的肺 perfusion 预测更好的运动中风体积在Fallote修复后的儿童

Elena Panaioli¹, Diala Khraiche², Neil Derridj²

¹Cardiologie pédiatrique, M3C-Necker, hôpital universitaire Necker-enfants malades, AP-HP, 149, rue de Sèvres, 75743 Paris cedex 15, France; Radiology Department, hôpital universitaire Necker-enfants malades, AP-HP, 75743 Paris, France.

Archives of cardiovascular diseases

|July 8, 2023

概括

在Fallote修复后向右不平衡的肺 perfusion 与更大的峰值指数运动中风体积 (pSVi) 有关. 这一发现有助于了解手术后年轻患者的运动限制.

科学领域:

心脏病学心脏病学
儿科心脏手术儿科心脏手术
心肺生理学心肺生理学

背景情况:

堕落后修复,肺吐和右心室外流通道阻塞是常见的残留病变.
这些病变可以通过损害左心室中风体积增大来限制运动耐受性.
肺 perfusion 不平衡对运动适应性的影响尚不清楚.

研究的目的:

为了研究肺 perfusion 不对称性和峰值指数运动中风体积 (pSVi) 之间的关联.
为了确定在Fallot四重法外科手术修复后的年轻患者的运动能力的预测因素.

主要方法:

对82名Fallot修复后患者 (平均年龄15.2岁) 的回顾性分析.
使用心声回声学,4D流MRI和心肺检测与生物阻抗 pSVi测量.
定义正常的肺流量分布为43%-61%的输液到右肺动脉.

主要成果:

63%的患者肺流分布正常,32%的患者向右,5%的患者向左.
右肺动脉输液显著预测了PSVi (β=0.368,P=0.0003).
其他预测因素包括右心室喷射分数,肺反分数,以及与肺缩的Fallot变异.

结论:

右肺动脉 perfusion 是一个显著的预测 pSVi 在患者后失败修复.
向右不平衡的肺输液与更大的PSVi有关.
这些发现有助于我们更好地理解这一群体的运动限制.

关键词:

4D 流动心脏磁共振心脏磁共振运动运动运动.肺 perfusion 的不对称性肺 perfusion 的不对称性冲击体积的冲击体积是如何形成的费洛特的四部曲费洛特四部曲

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