应用CIBMTR 一年生存结果计算器作为追溯分析工具
Christina Cho1, Sean Devlin2, Molly Maloy3
1Department of Medicine, Stem Cell Transplantation and Cellular Therapy Service, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA.
Bone marrow transplantation
|July 8, 2023
概括
CIBMTR 一年生存结果计算器准确地预测了针对白血病和MDS的全源造血细胞移植 (HCT) 后的一年生存率. 该工具为个性化患者咨询和治疗规划提供可靠的数据.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 全基性造血细胞移植 (HCT) 是血液恶性瘤的关键治疗方法.
- 准确预测生存结果对于患者咨询和治疗决策至关重要.
- 国际血液和骨髓移植研究中心 (CIBMTR) 开发了一款基于网络的计算器,用于估计1年生存概率.
研究的目的:
- 评估CIBMTR 一年生存结果计算器的校准和准确性.
- 为了评估计算器的性能,我们使用了成年患者进行AML,ALL或MDS的HCT后期数据来评估计算器的性能.
- 为了确定计算器是否可以可靠地应用于更大的患者队列.
主要方法:
- 对在2000-2015年期间在单一中心接受首次针对AML,ALL或MDS的全基性HCT的成年患者的回顾性分析.
- 使用的外周血液干细胞移植 (PBSCT) 来自7/8或8/8匹配的捐赠者.
- 使用CIBMTR计算器对每个患者预测的1年总生存期 (OS) 的估计.
- 估计使用卡普兰-梅尔法和加权卡普兰-梅尔估计器观察到的1年的OS.
主要成果:
- 根据CIBMTR的一年生存结果计算器,预测和观察的一年生存结果之间存在普遍一致.
- 计算器的预测在应用于更大的患者队列时被发现是可靠的.
- 这项研究是首次在此类数据上对计算器进行验证的分析.
结论:
- CIBMTR 一年生存结果计算器是预测AML,ALL和MDS患者HCT后1年生存期的宝贵工具.
- 该计算器为个性化患者咨询提供了数据驱动的基础.
- 该工具的准确性支持其在临床实践中的应用,以提供知情决策.
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