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Multi-Modal Home Sleep Monitoring in Older Adults
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在患有神经退行性疾病的患者中检测偶发性夜间超
Hiroyuki Naito1,2, Takamichi Sugimoto3,4, Kazuki Kimoto1
1Department of Neurology, Hiroshima City Hiroshima Citizens Hospital, 7-33 Motomachi, Naka-ku, Hiroshima, Hiroshima, 730-8518, Japan.
Sleep & breathing = Schlaf & Atmung
|July 8, 2023
概括
情节性夜间高头 (eNH) 是常见的神经退行性疾病,如ALS和MSA与睡眠相关的呼吸障碍. 通过皮肤对二氧化碳的监测可以检测这些患者的低通风.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 肺部病理学 肺部病理学
背景情况:
- 情节性夜间高头 (eNH) 是夜间低通风的一个生物标志物.
- 关于eNH和神经退行性疾病与睡眠相关呼吸障碍 (SRBD) 之间的关联尚不清楚.
研究的目的:
- 研究神经退行性疾病患者的ENH和夜间低通风之间的关系.
主要方法:
- 在110名患有各种神经退行性疾病的患者中,进行了一夜间通过皮肤的二氧化碳压力 (PtcCO2) 监测.
- 根据疾病 (ALS,MSA,其他) 和eNH和睡眠相关低通风 (SH) 的存在,患者被分为几组.
主要成果:
- 23%的患者表现出ENH,9%的患者有SH.
- 与其他神经退行性疾病相比,在ALS和MSA患者中,eNH和SH的患病率明显高.
- 在NNH和SH之间观察到强烈的相关性,39%的NNH患者有SH,90%的SH患者表现出NNH.
结论:
- eNH在神经退行性疾病 (如MSA和ALS) 中经常发生,特别是在SRBD患者中.
- 一夜间PtcCO2监测和ENH检测作为有价值的生物标志物,用于识别具有不同SRBD机制的多种神经退行性疾病中的低通风.
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