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Updated: Jul 24, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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翻译后拼接修改作为急性骨髓性白血病中细胞氨酸耐药性的关键机制

María Luz Morales1, Roberto García-Vicente2, Alba Rodríguez-García2

  • 1Department of Translational Hematology, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Hematological Malignancies Clinical Research Unit H12O-CNIO, Hospital 12 de Octubre - Centro Nacional de Investigaciones Oncológicas, CIBERONC, ES 28041, Madrid, Spain. marimo13@ucm.es.

Leukemia
|July 8, 2023
PubMed
概括

在急性髓性白血病 (AML) 中的cytarabine耐药性涉及改变的RNA剪接和富含氨酸和氨酸 (SR) 的蛋白质酸化. 拼接抑制剂在治疗AML方面表现有前途,组合疗法显示出显著的疗效.

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