儿科移植接受者的代谢酸
Stella Kilduff1,2, Nicole Hayde3, Shankar Viswanathan4
1The Children's Hospital at Montefiore/Einstein, Bronx, NY, USA. skilduff@montefiore.org.
Pediatric nephrology (Berlin, Germany)
|July 8, 2023
概括
代谢性酸症在儿童移植接受者 (KTRs) 在第一年内很常见. 这种情况与随访期间功能 (eGFR) 显著下降有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 儿科移植 儿科移植
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢性酸症是慢性病和成年移植患者功能下降的已知危险因素.
- 儿科移植接受者 (KTRs) 中代谢酸性的患病率和影响仍然不太清楚.
研究的目的:
- 调查儿科KTR中代谢酸性的流行情况.
- 在这个人群中确定代谢酸和全移植功能之间的关联.
主要方法:
- 一项回顾性研究包括从2010年到2018年的儿科KTR.
- 代谢性酸化被定义为血清二碳酸盐<22mEq/L或接受性疗法.
- 以人口统计和移植相关因素调整后的回归模型.
主要成果:
- 在基线时,代谢性酸性的流行率为44%,在移植后的第一年从58-70%不等.
- 移植时的年龄较大与较低的酸性病的几率有关.
- 在随访期间,代谢性酸独立预测了8.2ml/min/1.73m2的较低EGFR.
结论:
- 在移植后的第一年,儿科KTR中代谢性酸的流行率很高.
- 在随访期间,代谢性酸性的存在与脏全移植功能 (eGFR) 的恶化有关.
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