相关实验视频

Updated: Jul 24, 2025

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

干扰的上皮透性作为严重COVID-19发展的预测因素

Duygu Yazici¹, Eren Cagan^2,3, Ge Tan¹

¹Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

|July 9, 2023

概括

表皮屏障完整性的生物标志物可以预测COVID-19的严重程度. 升高的细菌DNA和zonulin家族 (ZFP) 表明严重的疾病,而完整的屏障表明较温和的过程,有助于早期入院预测.

科学领域:

胃肠道学和传染病研究
对炎症状况的生物标志物发现

背景情况:

胃肠道上皮质屏障功能障碍与炎症性疾病有关.
评估表皮屏障完整性生物标志物可以预测COVID-19的严重程度.

研究的目的:

评估表皮屏障功能障碍生物标志物,用于预测严重的COVID-19.
为了确定COVID-19疾病进程的早期预测标记.

主要方法:

在328名COVID-19患者和49名对照组中分析了血清细菌DNA和zonulin家族 (ZFP).
测量了180种免疫和炎症蛋白质.
利用蛋白质组分析检测疾病进展标志物.

主要成果:

严重的COVID-19病例显示出明显更高的循环细菌DNA.
较高的ZFP水平是COVID-19患者的特征.
鉴定了六种蛋白质 (AREG,AXIN1,CLEC4C,CXCL10,CXCL11,TRANCE) 与细菌转位有很强的相关性,用于预测严重疾病 (AUC: 1).
在中度至重症病例中,十种蛋白质被确定为疾病进展和死亡率的预测因子 (AUC:0.88).

结论:

表皮屏障状态的生物标志物与COVID-19的严重程度有关.
这些生物标志物在入院时提供了早期预测信息.

关键词:

在 COVID-19 疫情中,细菌的 DNA 是细菌的 DNA.生物标志物生物标志物表面上皮质屏障的一个障碍.佐努林家族的酸是佐努林家族的酸.

更多相关视频

Testing Epithelial Permeability in Fetal Tissue-Derived Enteroids

Testing Epithelial Permeability in Fetal Tissue-Derived Enteroids

Published on: June 16, 2022

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

相关概念视频

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Tight Junctions

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...