过敏征程的不同起点:食物蛋白质诱导的过敏性直肠炎
Semiha Bahceci1, Pınar Kuyum Töz2, Figen Celebi Celik3
1Department of Pediatric Allergy and Immunology, Çiğli Training and Research Hospital, Izmir Bakırçay University, Faculty of Medicine, Izmir, Turkey.
Allergologia et immunopathologia
|July 9, 2023
概括
食物蛋白诱导过敏性口腔炎 (FPIAP) 患者患长期过敏疾病和功能性胃肠道疾病 (FGIDs) 的风险增加. 早期的耐受性发展对于更好的结果至关重要,因为延迟的耐受性与更高的FGID和过敏疾病患病率有关.
科学领域:
- 儿科过敏和免疫学
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
背景情况:
- 食物蛋白诱导的过敏性乳头炎 (FPIAP) 是婴儿的非IgE介导的胃肠道食物过敏.
- 在FPIAP患者中,长期的结果和发展其他过敏或胃肠道疾病的风险尚未得到充分确立.
- 了解FPIAP的轨迹对于识别过敏征程的潜在风险因素至关重要.
研究的目的:
- 调查被诊断患有FPIAP的儿童的长期预后.
- 评估在FPIAP患者中发展并发性过敏和胃肠道疾病的风险.
- 为了确定FPIAP是否有助于过敏症的发展.
主要方法:
- 一项队列研究涉及149名有FPIAP病史的儿童 (至少耐受5年) 和41名健康对照.
- 在这两组人群中,对过敏性疾病和胃肠道疾病进行全面的重新评估.
- 与FPIAP诊断年龄,耐受性年龄和并发症的存在有关的疾病发展的分析.
主要成果:
- 与对照组相比,FPIAP患者的并发性过敏性疾病发病率明显高 (P < 0.001).
- 在功能性胃肠道疾病 (FGIDs),eosinophilic胃肠道疾病或炎症性肠道疾病的患病率方面,没有观察到群体之间的显著差异.
- 在FPIAP患者中,延迟耐受性发展 (>18个月) 与FGID和过敏疾病的比例显著增加有关 (P<0.001).
结论:
- FPIAP患者在晚年生活中患过敏疾病和FGID的风险增加.
- 在FPIAP患者中发生过敏性疾病的发生与诊断时存在过敏性疾病有关.
- 在FPIAP中对食物蛋白质的延迟耐受性是长期胃肠道和过敏性疾病的重要危险因素.
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