在德国的现实世界多中心环境中,在使用inclisiran后,LDL胆固醇降低的高个体间变异性
U Makhmudova1,2,3,4, U Schatz5, N Perakakis5,6,7
1Department of Internal Medicine I, Division of Cardiology, Angiology and Intensive Medical Care, Friedrich-Schiller-University, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.
概括
在德国患者中,Inclisiran有效降低低密度脂蛋白胆固醇 (LDL-C),尽管个体差异很大. 需要进行进一步的研究,以了解高胆固醇血治疗功效的这些差异.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 遗传学 是一个遗传学.
背景情况:
- 低密度脂蛋白胆固醇 (LDL-C) 是高胆固醇血症管理的主要目标.
- 英克利西兰是一种小干扰RNA (siRNA) 治疗药物,其向PCSK9mRNA,以减少循环中的LDL-C.
- 随机试验显示inclisiran可以显著降低LDL-C水平.
研究的目的:
- 评估用inclisiran治疗的现实德国队列中的LDL-C降低.
- 评估inclisiran在临床环境中的疗效和耐受性.
- 确定影响inclisiran在治疗高胆固醇血症中的有效性因素.
主要方法:
- 在14个德国脂质诊所接受inclisiran的153名患者的分析 (2021年2月 - 2022年7月).
- 基线特征的描述,管理后3个月和9个月的LDL-C变化.
- 对副作用的监测和患者子组之间的疗效比较.
主要成果:
- 中位数LDL-C降低3个月后为35.5%,9个月后为26.5%.
- 在以前接受PCSK9抗体治疗的患者中观察到较低的疗效 (23.6%对41.1%).
- 同时使用他类药物治疗与较大的LDL-C降低相关;观察到高个体间变异性. 英克利西兰耐受性良好,罕见的副作用 (5.9%).
结论:
- 在实际的德国人群中,Inclisiran显示出显著的LDL-C降低.
- 观察到治疗反应的高个体间变异性.
- 需要进一步的研究,以了解inclisiran治疗的可变疗效的驱动因素.
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