心率变化:心力衰竭患者临床形状和死亡率的参考值和作用
Silav Zeid1,2, Gregor Buch1,2,3, David Velmeden1,2
1Preventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
概括
心率变化 (HRV) 标志物预测心力衰竭患者的死亡率. 非线性HRV测量,包括加速和减速能力,是生存的强有力的独立预测指标.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 心率变化 (HRV) 是自主神经系统功能的一个关键指标.
- 确定参考值和了解HRV的决定因素对于临床应用至关重要,特别是在心力衰竭中.
- 以前的研究集中在时间和频率域HRV标记上,但数据驱动的方法可能会揭示新的见解.
研究的目的:
- 确定心力衰竭患者心率变化 (HRV) 测量指标的基准值和临床决定因素.
- 评估HRV对临床结果的预测相关性,特别是所有原因的死亡率,在这个人群中.
主要方法:
- 利用了来自前性MyoVasc研究 (NCT04064450) 的数据,该研究涉及3289名患有慢性心力衰竭的参与者.
- 通过系统文献审查和数据驱动方法选择HRV标记,参考值来自健康的亚样本.
- 用多变量线性回归用于HRV决定因素和多变量Cox回归用于死亡率预测.
主要成果:
- 分析包括1001名参与者 (平均年龄64.5岁,35.4%为女性) 用霍尔特心电图记录.
- 一种数据驱动的方法将主要的非线性HRV指标确定为显著的.
- 年龄,性别,失脂症,家族病史,外围动脉疾病和心力衰竭状态与HRV有很强的关联.
- 加速能力,减速能力和时间延迟成为6.5年来所有原因死亡率最强的独立预测因素.
结论:
- HRV标志物与心力衰竭患者的心血管临床概况有显著的相关性.
- 具体的HRV测量,特别是加速能力,减速能力和时间延迟,是生存的强大和独立的预测指标.
- 这些发现突显了针对HRV的治疗干预措施在心力衰竭管理中的临床相关性和潜力.
更多相关视频
05:15Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
132
05:48Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
Published on: September 21, 2018
10.2K
相关概念视频
01:30Factors Influencing Heart Rate
2.9K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
2.9K
01:26Heart Failure III: Clinical Manifestations
24
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
24
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:30Heart Failure IV: Classification and Diagnostic Evaluation
20
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
20
01:31Regulation of Heart Rates
1.9K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
1.9K
01:17Increased pulse rate
694
Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
694