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胸部CT期间的机会性肌肉评估与老年人脊椎压缩骨折有关:一项纵向研究

Miaomiao Wang^1,2, Hongye Tang¹, Xin Chen³

¹Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

The journals of gerontology. Series A, Biological sciences and medical sciences

|July 9, 2023

概括

标志着勃起脊柱肌面积减少的萨科佩尼亚与老年人脊椎压力骨折 (VCF) 的风险较低有关. 肌肉测量可以改善骨折预测模型.

科学领域:

老年学是一门学科.
放射学放射学是一门学科.
整形外科整形外科整形外科

背景情况:

在老年人群中,肉症和骨质损失很普遍.
萨尔科佩尼亚和骨折之间的纵向关系仍未得到充分研究.
这项研究调查了勃起脊柱肌肉特征与脊椎压缩骨折 (VCF) 之间的联系.

研究的目的:

评估基于计算机断层扫描 (CT) 的勃起脊柱肌区域与老年人新发性VCF衰减之间的关联.
为了确定肌肉特征是否可以独立于骨密度来预测VCF.
在VCF预测模型中评估肌肉面积的增量值.

主要方法:

在基线没有VCF的50岁以上个体进行长度研究,接受CT肺癌查.
测量了勃起脊柱肌面积和CT衰减.
使用Genant评分识别的新发风险投资基金.
考克斯的比例危险模型分析了肌肉参数和VCF风险之间的关联.

主要成果:

一个大勃起脊柱肌的区域独立地与VCF风险降低相关 (aHR=0.2).
高度的骨衰减也独立地与降低的VCF风险相关 (aHR=0.2).
增加的肌肉面积显著改善了对VCF骨衰减的预测性能 (AUC从0.79增加到0.86).

结论:

通过CT评估勃起脊柱肌的区域和衰减是老年人中VCF的显著预测因素.
肌肉参数为VCF风险评估提供了有价值的信息,独立于骨密度.
将肌肉区域纳入预测模型可以提高VCF风险分层的准确性.

关键词:

骨质量骨质量骨质量计算机断层扫描 (CT) 是一种计算机断层扫描.质量质量的肌肉质量.脊椎压缩骨折是指脊椎的压缩骨折.

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