探索桃体亚核体积与左侧叶症的认知表现之间的关系,有或没有海马硬化
Alice Ballerini1, Francesca Talami2, Maria Angela Molinari3
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Epilepsy & behavior : E&B
|July 9, 2023
概括
时间叶 (TLE) 的认知缺陷与杏仁体体积变化有关. 带有海马硬化症的TLE (TLE-HS) 中的缩会影响记忆力,而非损伤性TLE (TLE-MRIneg) 中的扩大会影响注意力和处理速度.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 的研究研究.
背景情况:
- 认知障碍是时间叶 (TLE) 的常见和严重并发症.
- 杏仁体的作用,一个关键的大脑结构,在TLE相关的认知障碍往往是研究不足.
- 在患有海马硬化症的TLE (TLE-HS) 与非损伤性TLE (TLE-MRIneg) 之间存在明显的杏仁核亚核参与模式.
研究的目的:
- 为了研究杏仁体和海马体子结构体积和左侧TLE患者的认知表现之间的关系.
- 根据TLE (带有或没有海马硬化症) 的病因学来区分这些关系.
主要方法:
- 招募了29名TLE患者 (14名TLE-HS,15名TLE-MRIneg) 并将他们的杏仁体和海马体体积与健康对照进行了比较.
- 分析了杏仁体和海马体子场体积和认知分数之间的关联,按TLE病因分层.
主要成果:
- 在TLE-HS中,底侧桃体和皮质桃体综合体的体积减少,以及海马缩,与较差的语言记忆相关.
- 在TLE-MRIneg中,桃体的普遍扩大,特别是在底侧和中心综合体中,与注意力和处理速度的缺陷有关.
结论:
- 杏仁体的结构异常与TLE的特定认知缺陷有显著的关系.
- 杏仁体的结构变化可能成为TLE中疾病进展和认知功能障碍的有价值的生物标志物.
更多相关视频
12:09Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
18.1K
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
15.0K
相关概念视频
01:15Functional Brain Systems: Limbic System
3.1K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.1K
01:19Role of Hippocampus in Memory
348
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
348
01:16Role of Amygdala in Memory
295
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
295