快速眼动睡眠行为障碍中的性别差异:系统性审查和元分析
Xiao Li1, Qiang Zong2, Liu Liu3
1Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Sleep Research Clinic and Laboratory, Department of Psychology, The University of Hong Kong, Hong Kong; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong.
Sleep medicine reviews
|July 9, 2023
概括
男人可能有更高的风险快速眼动 (REM) 睡眠行为障碍 (RBD),特别是老年人. 这次系统性审查探讨了RBD患病率和特征的性别差异.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 快速眼动 (REM) 睡眠行为障碍 (RBD) 通常被认为是男性占主导地位的疾病.
- 关于一般人群患RBD风险的性别差异存在相互矛盾的证据.
研究的目的:
- 系统地审查和分析RBD患病率,并发症,临床特征和变异性转化中的性别差异.
- 为了澄清RBD在性别之间的流行病学和临床区别.
主要方法:
- 133项符合条件的研究的系统审查和元分析.
- 包括检查不同人群中RBD患病率,临床特征和转换的研究.
主要成果:
- 在男性,特别是老年人 (≥60) 中,更高的可能/可能RBD (pRBD) 风险的趋势.
- 在临床男性群体中,确诊RBD的风险显著增加,但不是pRBD.
- 患有异形性RBD (iRBD) 的男性更早出现.
- 男性帕金森病 (PD) 患者有伴随性RBD的风险增加.
结论:
- 在RBD风险和特征方面的性别差异需要进一步调查.
- 需要采用严格标准的前性研究来证实发现并探索潜在机制.
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