孕期孕的代谢物:与围产期焦虑的关联
Semra Etyemez1, Kristen N Miller2, Kristin M Voegtline3
1Department of Obstetrics & Gynecology, Weill Cornell Medicine, 525 E. 68th St., M-706, New York, NY 10065, USA; Department of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Psychoneuroendocrinology
|July 9, 2023
概括
孕妇周产期焦虑与神经活性类固醇 (NAS) 代谢的改变有关,特别是将孕激素转移到全原. 这项研究探讨了在没有伴随性抑郁症的情况下,这些焦虑的生物学因素.
科学领域:
- 神经内分泌学神经内分泌学
- 围产阶段精神病学 围产阶段精神病学
- 代谢学 代谢学 代谢学
背景情况:
- 围产期焦虑症是常见的,也是产后抑郁症的危险因素.
- 对于围产期焦虑的生物学因素,特别是神经活性类固醇 (NAS) 失调,人们知之甚少.
- 之前对围产期精神疾病中NAS的研究缺乏明确的方向性,并没有排除伴随性抑郁症.
研究的目的:
- 在周产期内纵向研究无伴随性抑郁症的焦虑与NAS的代谢途径之间的关联.
- 检查焦虑如何影响孕激素转化为其代谢产物.
主要方法:
- 测量了36名患有焦虑症的妇女和38名控制者的焦虑症状和NAS水平,在产后的第二个和第三个三个月和6周期间.
- 用于NAS量化使用的气相色谱-质谱法 (GC-MS).
- 采用横截面和纵向统计分析,包括AKR1C2基因的基因型分析.
主要成果:
- 焦虑显著缓解了孕激素到阿洛普雷格纳诺龙的途径,将新陈代谢转向阿洛普雷格纳诺龙.
- 在焦虑组中,在第三个三个月和产后期间,阿洛普雷格纳诺龙与孕激素比例的下降不那么急剧.
- 基因型分析显示,AKR1C2基因影响了阿洛普雷格纳诺龙及其中间代谢物5α-DHP之间的关系.
结论:
- 探索性发现表明,患有焦虑症的孕妇会表现出更具侵略性的代谢转移,从孕激素转向allopregnanolone.
- 这种改变的代谢途径可能是导致围产期焦虑的生物学因素.
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