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桃体切除术后出血的治疗与雾化松酸:一个回顾性研究
Timothy J Shin1, Fahad Hasnain2, Elizabeth O Shay1
1Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University School of Medicine, Indianapolis, IN, USA.
概括
雾化松酸 (TXA) 显著降低了手术的需要,并在患有桃体切除术后出血 (PTH) 的患者中重复出血. 这种治疗提供了一种有希望的,安全的方法来有效地管理PTH.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术出血管理手术出血管理
- 药理干预药理干预
背景情况:
- 桃体切除术后出血 (PTH) 是需要干预的常见并发症.
- 目前对PTH的管理策略各不相同,操作干预是一个重大问题.
研究的目的:
- 评价雾化松酸 (TXA) 在降低桃体切除术后出血 (PTH) 的手术干预率方面的疗效.
主要方法:
- 这是一项回顾性队列研究,比较了用雾化TXA和标准护理治疗的PTH患者与仅接受标准护理的对照组.
- 分析包括2015年至2022年间被诊断患有PTH的成人和儿科患者.
主要成果:
- 雾化TXA治疗与手术室 (OR) 干预率显著降低 (36.1%与60.2%,p < 0.0001).
- 接受TXA治疗的患者出现的重复出血事件较少 (4.9%对14.2%,p < 0.02).
- 用TXA进行OR干预的几率比为0.37 (95% CI为0.22,0.63),没有发现任何不良影响.
结论:
- 雾化松酸 (TXA) 是一种有效的治疗桃体切除术后出血 (PTH),减少了手术干预和重复出血的需要.
- 需要进一步的前性研究来证实疗效,并建立在PTH管理中雾化TXA的最佳治疗方案.
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