人类头发链截面中的金属分布:使用LA-ICP-MS在牙科中的高级分析
Ana Carla B C J Fernandes1, Panseok Yang2, Debbie Armstrong3
1Department of Oral Biology, College of Dentistry, University of Manitoba, Winnipeg, Canada.
Talanta
|July 9, 2023
概括
对有毒金属的人类头发分析至关重要. 毛发截面的完全激光切除感应合等离子体质谱法 (LA-ICP-MS) 对于精确的元素造型,特别是在牙科环境中更优越.
科学领域:
- 环境科学 环境科学
- 分析化学 分析化学
- 生物标记分析 生物标记分析
背景情况:
- 人类头发是评估有毒金属暴露的关键生物标志物.
- 以前对头发元素分析的研究经常使用部分切除,由于元素分布不均,可能导致不准确的结果.
- 牙科环境给工人和学生带来了对有毒金属的独特暴露风险.
研究的目的:
- 为了研究人类头发截面内的元素变化.
- 为了比较完全与部分激光切除的精度,用于头发分析的感应合血质谱法 (LA-ICP-MS).
- 验证一种新的LA-ICP-MS方法,用于监测牙科专业人员的金属暴露.
主要方法:
- 在人头发中分析了13种元素 (Li,Mg,Cr,Mn,Fe,Co,Ni,Cu,Zn,Sr,Ag,Ba,Hg),使用激光除感应合等离子体质谱法 (LA-ICP-MS).
- 对LA-ICP-MS进行全切除与部分切除技术的比较.
- 对LA-ICP-MS结果与溶液雾化诱导合血质谱法 (SN-ICP-MS) 的验证.
主要成果:
- 在人类头发线上观察到显著的内部元素变化.
- 发现大多数元素都在头发皮质上得到了丰富.
- 完整的LA-ICP-MS与SN-ICP-MS相比,与部分消去相比,显示出更好的协议.
- 开发的LA-ICP-MS方法对于头发元素分析是可靠的.
结论:
- 为了准确地描述人类头发的元素化学,完全切除是必不可少的.
- 经过验证的LA-ICP-MS方法为牙科工作人员和学生的生物监测提供了一个强大的工具.
- 这项研究强调了在评估有毒金属暴露时,在头发分析中严格的方法的重要性.
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