治疗结束时的微生物学治愈与患有Mycobacterium avium复杂肺部疾病的患者的寿命延长有关
Joong-Yub Kim1, JiWon Park2, Yunhee Choi2
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Chest
|July 9, 2023
概括
在由Mycobacterium avium复合体 (MAC) 引起的非结核性菌根性肺病 (NTM-PD) 中实现微生物治疗与显著更长的生存时间有关. 这一发现凸显了治疗成功对长期患者结果的重要性.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 非结核性菌根性肺病 (NTM-PD) 是一个日益严重的健康问题,Mycobacterium avium复合体 (MAC) 是最常见的致病原体.
- 虽然微生物学结果是评估治疗疗效的标准,但它们的长期预后影响仍然不清楚.
研究的目的:
- 调查在MAC相关的NTM-PD患者中实现微生物治疗是否与改善的长期存活相关.
主要方法:
- 对382名患有MAC-PD的成年患者进行了回顾性分析,他们接受了至少12个月的基于宏类的疗法治疗.
- 微生物学治愈被定义为三个或更多连续的负培养,间隔至少4周,没有治疗后的阳性培养.
- 使用多变量Cox比例危险回归来评估微生物治愈和全因死亡率之间的关联,并调整临床因素.
主要成果:
- 在382名患者中,236名 (61.8%) 实现了微生物治疗.
- 治愈的患者年轻,炎症标志物不那么严重.
- 在平均3.2年的随访期间,微生物治疗显著与所有原因死亡率的降低有关 (调整后的危险比率,0.52;95% CI,0.28-0.94).
结论:
- 在MAC-PD治疗结束时实现的微生物学治愈是改善长期生存的重要预测因素.
- 这些发现强调了微生物根除在管理NTM-PD中的预后价值.
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