人类结构连接体的枢纽架构:与衰老和处理速度的联系
Xin Li1, Alireza Salami2, Jonas Persson3
1Aging Research Center, Karolinska Institute and Stockholm University, Stockholm 171 65, Sweden.
NeuroImage
|July 9, 2023
概括
老龄化特别影响大脑.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 大脑连接学 (Connectomics)
背景情况:
- 人类大脑表现出一个丰富的俱乐部组织,高度连接的枢纽对认知至关重要.
- 衰老与认知能力下降以及大脑结构和功能的变化有关.
- 衰老对这些关键大脑枢纽的连接的影响仍然不清楚.
研究的目的:
- 研究老龄化如何影响人类结构连接体中的枢纽连接.
- 探索老化,枢纽连接和处理速度之间的关系.
主要方法:
- 使用由受约束球形解卷 (CSD) 衍生的纤维捆容量 (FBC) 构建结构连接体.
- FBC量化了白质纤维捆中的信息传输能力.
- 分析了截面 (N=137) 和纵向 (N=83) 的衰老队列.
主要成果:
- 大脑枢纽显示较长距离的连接和更高的新陈代谢率,表明显著的能源成本.
- 虽然枢纽结构是年龄不变的,但观察到与年龄相关的FBC普遍下降,特别是在枢纽连接内.
- 枢纽连接中的FBC减少与处理速度减慢和与年龄相关的衰退有关.
结论:
- 大脑中心的结构连接,尽管它们的能量需求很高,但特别容易受到衰老的影响.
- 枢纽连接中的这种漏洞可能是年龄相关的处理速度损害的基础.
- FBC提供了一种敏感的测量方法,用于检测与年龄相关的脑网络完整性的变化.
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