在患有索马托罗普腺瘤的患者中,术后认知和情感功能的特征
Bo Wang1, Zhixu Bie1, Xingchao Wang1
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
World neurosurgery
|July 9, 2023
概括
患有体腺瘤 (SAs) 的患者因生长激素过量而表现出认知缺陷和情绪障碍. 手术在SA患者中为这些功能提供了有限的短期改善.
科学领域:
- 神经内分泌学神经内分泌学
- 认知神经科学 认知神经科学
- 外科手术的结果
背景情况:
- 索马托罗普腺瘤 (SAs) 导致过多的生长激素 (GH) 分泌,可能会影响认知和情感功能.
- 了解这些影响对于患者管理和治疗策略至关重要.
研究的目的:
- 评估SAS患者的认知和情感功能.
- 评估手术干预对SA患者这些功能的影响.
主要方法:
- 展望纵向研究比较了27名SA患者,29名非功能性垂体腺瘤 (NFPA) 患者和24名健康对照 (HC).
- 在手术前和后 (3个月) 进行了多维认知和神经心理评估.
- 测试包括对记忆,执行功能,焦虑和情绪的评估.
主要成果:
- 与HC相比,SA患者在记忆和焦虑方面表现较差.
- 在SA和NFPA患者之间没有发现显著的认知或情感差异.
- 与NFPA患者不同的是,SA患者在手术后没有显著的认知或情感改善.
结论:
- 存在特定认知缺陷和情绪异常的SA患者,可能与GH过度生产有关.
- 手术干预对改善SA患者的认知和情感障碍的短期效果有限.
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