黄色鼓 (Nibea albiflora) 中的一种C型莱克类受体CD302,具有抗菌活性和先天免疫信号传递功能
Jia Peng1, Jiacheng Li1, Jingjie Liang1
1Key Laboratory of Healthy Mariculture for the East China Sea, Fujian Provincial Key Laboratory of Marine Fishery Resources and Eco-environment, Fisheries College, Jimei University, Xiamen 361000, China.
International journal of biological macromolecules
|July 9, 2023
概括
一个黄色的鼓,一个黄色的鼓.
科学领域:
- 水产养殖免疫学 水产养殖免疫学
- 鱼类疾病耐药性 鱼类疾病耐药性
- 宿主-病原体相互作用
背景情况:
- 杆菌harveyi感染对黄色鼓水产养殖构成重大威胁.
- 之前的研究已经确定了黄色鼓中的C型类似actin的受体集群的分化CD302 (YdCD302).
- 了解YdCD302的作用对于增强抗病能力至关重要.
研究的目的:
- 为了研究YdCD302在黄色鼓中的基因表达模式.
- 阐明 YdCD302 在防御 Vibrio harveyi.yi 的功能作用.
- 探索YdCD302介导免疫的基础分子机制.
主要方法:
- 在各种组织中进行基因表达分析.
- 基于蛋白质的凝结和抗菌分析.
- 具有约束力的测试来评估YdCD302与V. harveyi.yi的相互作用.
- 对反应性氧物种 (ROS) 生产和下游信号通路的分析.
主要成果:
- YdCD302分布广泛,在肝脏表达最高.
- YdCD302蛋白显示出对V. harveyi.yi.的结合和抗菌活性.
- YdCD302与V. harveyi相互作用,诱导ROS的产生和ReCA/LexA介导的细菌细胞死亡.
- 感染后,YdCD302的表达在免疫器官上调,可能会激活先天免疫细胞因子.
结论:
- YdCD302在黄鼓对抗V. harveyi感染的防御中发挥着至关重要的作用.
- 这种类型C的甲酸样受体CD302调解细菌的识别,并触发细胞死亡途径.
- 鉴定YdCD302的特征有助于更好地了解鱼类的疾病耐药性,并为疾病控制策略提供信息.
相关概念视频
01:31Immunoglobulin-like Cell Adhesion Molecules
3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
01:25Cell Signaling in Plants
5.7K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.7K
01:30Bacterial Signaling
32.9K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
32.9K
01:25Selectins
3.4K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.4K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.5K
01:39Receptor-mediated Endocytosis
104.7K
Overview
104.7K