通过多糖和蛋白质的自我组装来实现粉纳米凝的功能:从合成到提供多的潜力
Jiejie An1, Mingzhu Liu1, Zia-Ud Din2
1National R&D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China.
International journal of biological macromolecules
|July 9, 2023
概括
碳基甲基粉-酶纳米凝被创造为提供生物活性化合物,如EGCG和酸. 这些天然蛋白质多糖纳米凝显示高封装和受控释放,显示出良好的生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 天然蛋白质和多糖体自组装成纳米凝,显示出生物活性分子传递的前景.
- 碳氧甲基粉-酶纳米凝 (CMS-Ly NGs) 为封装和输送治疗化合物提供了一个潜在的平台.
研究的目的:
- 使用绿色静电自组装方法制备碳氧甲基粉-酶纳米凝 (CMS-Ly NGs).
- 评估CMS-Ly NGs作为表甲基酸盐 (EGCG) 和酸的输送系统.
- 描述开发的纳米凝的结构性,热性和释放性.
主要方法:
- 碳氧甲基粉和酶的静电自组装.
- 使用动态光散射 (DLS), ζ-潜在,FT-IR,XRD和TGA进行表征.
- 封装效率,在模拟的胃肠道条件下进行受控释放研究,以及细胞毒性测定.
主要成果:
- 成功合成了CMS-Ly NGs,其EGCG封装效率高 (80.0 ± 1.4%).
- 这些纳米凝具有稳定的粒子大小,规律的球形结构和良好的热稳定性.
- 在模拟的胃肠道条件下观察到EGCG和安东素的受控释放,这表明利用率提高.
- 细胞毒性测定证实了CMS-Ly NGs的良好生物相容性.
结论:
- 碳氧甲基粉-酶纳米凝是生物活性化合物的有效载体,如EGCG和酸.
- 绿色静电自组装方法为纳米凝制备提供了一个简单的途径.
- 这些蛋白质多糖纳米凝显示出在生物活性化合物输送系统中应用的巨大潜力.
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