矩阵金属蛋白酶-9调节了关动脉的重塑和功能,在高血压引起的脏疾病
Wenguang Feng1, Zhengrong Guan1, Wei-Zhong Ying1
1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kidney international
|July 9, 2023
概括
矩阵金属蛋白酶-9 (MMP-9) 在高血压中驱动脏微血管损伤. 抑制MMP-9可以保护达尔大鼠免受高血压脏疾病和球损伤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管生物学 心血管生物学
- 分子医学是分子医学.
背景情况:
- 高血压病涉及微血管病理.
- 矩阵金属蛋白酶-9 (MMP-9) 参与了血管重塑.
研究的目的:
- 调查MMP-9在启动高血压病中的作用.
- 为了确定MMP-9是否在对盐敏感的达尔大鼠中促进微血管病理.
主要方法:
- 对盐敏感的达尔大鼠,野生型和Mmp9缺乏,被食高盐饮食.
- 评估了血压,脏微血管基因表达 (Tgfb1,Mmp9),蛋白质标记物 (-Smad2) 和纤维素沉积.
- 评估了不同的动脉自调和质标记物 (威尔姆斯瘤1,多多辛,尼弗林).
主要成果:
- 两组的高血压发展相似,但MMP-9缺乏阻止了微血管光滑肌肉细胞转化和促炎分子上调.
- 缺少MMP-9保留了 afferent动脉自调节,并保护了对球损伤的保护,这是由保存的威尔姆斯瘤1细胞和减少的尿波多辛/尼弗林mRNA所表明的.
- 实验室研究表明,MMP-9抑制可以防止循环菌株诱导的TGF-β1激活和Smad2/3酸化.
结论:
- 在高血压引起的脏微血管改造中,MMP-9起着至关重要的作用.
- 在高血压脏疾病的背景下,MMP-9有助于球上皮细胞损伤.
- 向MMP-9可能为高血压脏疾病提供治疗策略.
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