胰岛素样生长因子-1和早产儿视网膜病变:系统性审查和元分析
Yanyan Fu1, Chunyan Lei1, Ran Qibo1
1Department of Ophthalmology, and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China.
Survey of ophthalmology
|July 9, 2023
概括
低胰岛素样生长因子-1 (IGF-1) 水平与早产性视网膜病变 (ROP) 的发展和严重程度有关. 在早产婴儿中监测IGF-1可以帮助ROP诊断和治疗.
科学领域:
- 新生儿科学 新生儿科学
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 在全球范围内,早产性视网膜病变 (ROP) 的患病率正在增加.
- 胰岛素样生长因子-1 (IGF-1) 和ROP之间的关联仍然存在争议.
研究的目的:
- 系统地评估IGF-1和ROP之间的相关性.
- 确定导致现有研究异质性的因素.
主要方法:
- 进行了元分析,搜索了多个数据库,直到2022年6月.
- 包括12篇涉及912名新生儿的文章.
- 进行了元回归和子组分析.
主要成果:
- 显著的异质性是由位置,IGF-1测量方法,血液采集时间和ROP严重程度解释的.
- 聚合分析表明,低IGF-1水平是ROP发展和严重性的风险因素.
结论:
- 在早产婴儿的血清IGF-1监测是有利于ROP诊断和治疗.
- 建议根据测量,区域和月经后年龄对IGF-1参考值进行标准化.
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